| 田玲琳，霍丽娟，韩晓栋.不同剂量氯沙坦治疗大鼠肝硬化门静脉高压症的实验研究[J].山西医科大学学报,2007,38(11):978~980 |
| 不同剂量氯沙坦治疗大鼠肝硬化门静脉高压症的实验研究 |
| Effect of different doses of losartan on port al hypertension in rats |
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| DOI： |
| 中文关键词: 高血压, 门静脉 氯沙坦；肝静脉压力梯度；肝硬化 |
| 英文关键词: hypertension, portal losartan hepatic venous pressure gradient liver cirrhosis |
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| 中文摘要: |
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目的 探讨不同剂量氯沙坦对肝硬化门静脉高压症大鼠的治疗作用。
方法 采用复合因素法制作大鼠肝硬化门静脉高压症（PHT）模型，43只雄性Wistar大鼠随机分为5组：正常对照组（n=7）、模型对照组（n=6）、三个治疗组分别给予10 mg/(kg· d)、 5 mg/(kg·d)、 2.5 mg/(kg·d)高、中、低三种剂量氯沙坦（各组n=10）。结果 治疗15 d结束后，与模型对照组比较，各治疗组肝静脉压力梯度（HVPG）均有显著下降（P<0.05），但仍高于正常对照组（P<0.05）。治疗组之间 比较差别无统计学意义。而高剂量组平均动脉压（MAP）从（94.44±11.23） mmHg下降到（ 70.81±12.57） mmHg。治疗组均可降低血清透明质酸（HA）的含量（P<0.05）。结论 氯沙坦能有效地降低HVPG，减轻肝纤维化而用于门静脉高压症的治疗。中、低剂量具有与高剂量类似的治疗效果，且对全身血流动力学影响小。
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| 英文摘要: |
| Objective To investigate the effects of different doses of losartan on portal hypertension
in rats.
Methods Portal hypertension（PHT） models were induced by compound factors. A total of 43 rats were randomly divided into five groups:contr
ol group(n=7),model group(n=6), three treatment groups(n=10 in eac h group). The rats in treatment groups were given different doses of losartan［ 10 mg/(kg·d), 5 mg/(kg·d), 2.5 mg/(kg·d)，respectively］.Results Compared with model group, hepatic venous pressure gradient(HVPG) in treatment groups significantly decreased after 15 d treatment(P<0.05), but it was still higher than in control group(P<0.05). T here was no signifi cant difference between three treatment groups. However, mean arterial pressure(MAP) decreased from （94.44±11.23）mmHg to （70.81±12.57）mmHg in high dose tr eatment group. Compared with model group, the level of serum HA significantly de creased in three treatment groups (P<0.05). Conclusion Losartan can effectively decrease HVPG. And medium and low doses of losartan h ave the same effect, but have less influence on systemic hemodynamics.
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