文章摘要
田玲琳,霍丽娟,韩晓栋.不同剂量氯沙坦治疗大鼠肝硬化门静脉高压症的实验研究[J].山西医科大学学报,2007,38(11):978~980
不同剂量氯沙坦治疗大鼠肝硬化门静脉高压症的实验研究
Effect of different doses of losartan on port al hypertension in rats
  
DOI:
中文关键词: 高血压, 门静脉  氯沙坦;肝静脉压力梯度;肝硬化
英文关键词: hypertension, portal  losartan  hepatic venous pressure gradient  liver cirrhosis
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作者单位
田玲琳,霍丽娟,韩晓栋 山西医科大学第一临床医学院消化科太原030001 
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中文摘要:
       目的 探讨不同剂量氯沙坦对肝硬化门静脉高压症大鼠的治疗作用。 方法 采用复合因素法制作大鼠肝硬化门静脉高压症(PHT)模型,43只雄性Wistar大鼠随机分为5组:正常对照组(n=7)、模型对照组(n=6)、三个治疗组分别给予10 mg/(kg· d)、 5 mg/(kg·d)、 2.5 mg/(kg·d)高、中、低三种剂量氯沙坦(各组n=10)。结果 治疗15 d结束后,与模型对照组比较,各治疗组肝静脉压力梯度(HVPG)均有显著下降(P<0.05),但仍高于正常对照组(P<0.05)。治疗组之间 比较差别无统计学意义。而高剂量组平均动脉压(MAP)从(94.44±11.23) mmHg下降到( 70.81±12.57) mmHg。治疗组均可降低血清透明质酸(HA)的含量(P<0.05)。结论 氯沙坦能有效地降低HVPG,减轻肝纤维化而用于门静脉高压症的治疗。中、低剂量具有与高剂量类似的治疗效果,且对全身血流动力学影响小。
英文摘要:
      Objective To investigate the effects of different doses of losartan on portal hypertension in rats. Methods Portal hypertension(PHT) models were induced by compound factors. A total of 43 rats were randomly divided into five groups:contr ol group(n=7),model group(n=6), three treatment groups(n=10 in eac h group). The rats in treatment groups were given different doses of losartan[ 10 mg/(kg·d), 5 mg/(kg·d), 2.5 mg/(kg·d),respectively].Results Compared with model group, hepatic venous pressure gradient(HVPG) in treatment groups significantly decreased after 15 d treatment(P<0.05), but it was still higher than in control group(P<0.05). T here was no signifi cant difference between three treatment groups. However, mean arterial pressure(MAP) decreased from (94.44±11.23)mmHg to (70.81±12.57)mmHg in high dose tr eatment group. Compared with model group, the level of serum HA significantly de creased in three treatment groups (P<0.05). Conclusion Losartan can effectively decrease HVPG. And medium and low doses of losartan h ave the same effect, but have less influence on systemic hemodynamics.
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