文章摘要
王丽1,卫建平2,李灵敏1,朱文源3,兰向昀1.浸润性乳腺癌中TRAIL及survivin的表达及意义[J].山西医科大学学报,2009,40(1):46~49
浸润性乳腺癌中TRAIL及survivin的表达及意义
Expression of TRAIL and survivin in invasive breast carcinoma and its significance
  
DOI:
中文关键词: 浸润性乳腺癌  TRAIL  survivin  免疫组化
英文关键词: invasive breast carcinoma  TRAIL  survivin  immunohistochemistry
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作者单位
王丽1,卫建平2,李灵敏1,朱文源3,兰向昀1 1山西医科大学病理教研室太原0300012山西医科大学第二临床医学院病理科3山西医科大学老干部处 
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中文摘要:
      目的〓 探讨TRAIL及survivin在浸润性乳腺癌中的表达,二者的关系及其临床意义。 〓方法〓 对49例浸润性乳腺癌组织及42例良性乳腺增生组织,采用免疫组织化学方法检测TRAIL及survivin的表达。 〓结果〓 TRAIL在浸润性乳腺癌中的表达明显低于良性乳腺增生组织(P<0.001),survivin在浸润性乳腺癌中的表达明显高于良性乳腺增生组织(P<0.001)。TRAIL与survivin表达之间呈负相关。TRAIL在浸润性乳腺癌组织中的表达与各种临床病理因素均无关,survivin在发生淋巴结转移的乳腺癌组织中的表达明显高于其在无淋巴结转移乳腺癌组织中的表达(P<0.05),与其他临床病理因素无关。 〓结论〓 与良性乳腺增生组织相比,浸润性乳腺癌组织中survivin表达上调,而TRAIL在癌组织中表达有丢失。通过抑制survivin的表达,有可能提高肿瘤细胞对TRAIL的敏感性。survivin蛋白在乳腺癌细胞的转移、侵袭等活动中可起到促进作用。
英文摘要:
      Objective〓 To investigate the expression of TNF related apoptosis inducing ligand(TRAIL)and survivin in invasive breast carcinoma and their correlation. 〓Methods〓 The expression of TRAIL and survivin was detected by immunohistochemistry(IHC)in 49 cases of invasive breast carcinoma and 42 cases of benign breast hyperplasia. 〓Results〓 The expression of TRAIL was significantly lower in invasive breast carcinoma than that in benign breast hyperplasia(P<0.001).The expression of survivin was significantly higher in invasive breast carcinoma than that in benign breast hyperplasia(P<0.001).TRAIL expression was negatively correlated with survivin expression,but not with clinicopathological features.The expression of survivin was higher in positive lymph node metastasis than those in negative lymph node metastasis. 〓Conclusion〓 The expression of survivin is up regulated in invasive breast carcinoma compared with that in benign breast hyperplasia,while TRAIL is down regulated.Down regulation of survivin expression may promote the sensitivity of anti tumor effect of TRAIL.Survivin may play an important role in the development and metastasis of cancer cells.
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