文章摘要
张玲荣.乙型肝炎患者310例肝纤维化与肝功能指标分析[J].山西医科大学学报,2009,40(1):67~69
乙型肝炎患者310例肝纤维化与肝功能指标分析
Dept of Infectious Diseases,First Clinical Medical College,Shanxi Medical University, Taiyuan 030001,China
  
DOI:
中文关键词: 乙型肝炎  肝纤维化  肝功能  透明质酸  Ⅳ型胶原
英文关键词: hepatitis B  liver fibrosis  liver function  hyaluronic acid  Ⅳ collagen
基金项目:
作者单位
张玲荣 山西医科大学第一临床医学院感染病科太原030001 
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中文摘要:
      目的〓 探讨肝纤维化与肝功能指标联合检测在肝病诊断中的应用价值。 〓方法〓 收集310例乙型肝炎病例,根据诊断分为急性肝炎组、慢性肝炎组、重型肝炎组、肝炎肝硬化组,检测患者的透明质酸(HA)、Ⅳ型胶原(Ⅳ C)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST),并与60例健康体检者做比较,分析各指标在乙型肝炎中的变化特点。 〓结果〓 各组乙型肝炎患者ALT、AST与对照组相比均明显升高(P<0.05),急性肝炎组的ALT、AST明显高于其余各组(P<0.01),慢性肝炎组、重型肝炎组及肝炎肝硬化组间ALT、AST水平比较无统计学差异(P>0.05)。各组乙型肝炎患者的HA、Ⅳ C平均值均较对照组明显升高(P<0.01),而且重型肝炎、肝炎肝硬化的HA、Ⅳ C指标平均值较急性肝炎明显升高(P<0.01)。HA、Ⅳ C与ALT、AST间均无相关性(P>0.05)。 〓结论〓 乙型肝炎患者血清肝功能指标异常,肝纤维化指标联合肝功能检测可提高临床对肝纤维化诊断的可靠性,有利于疾病演变的监测和治疗。
英文摘要:
      Objective〓 To explore the diagnostic value of the combined detection of hepatic fibrosis and liver function indices for hepatic diseases. 〓Methods〓 A total of 310 hepatitis B patients were divided into acute hepatitis group,chronic hepatitis group,severe hepatitis group,cirrhosis group according to diagnosis.Hyaluronic acid(HA),Ⅳ collagen(Ⅳ C),alanine aminotransferase(ALT),aspartate aminotransferase(AST)were measured.Sixty healthy subjects were chosen as control group. 〓Results〓 The levels of ALT and AST significantly increased in patients with hepatitis B compared with that of healthy controls(P<0.05).The levels of ALT and AST in acute hepatitis patients were significantly higher than that in the other hepatitis patients(P<0.01),but there was no significant difference between patients with chronic hepatitis,severe hepatitis and cirrhosis(P>0.05).The levels of HA and Ⅳ C were significantly higher in hepatitis B patients than that of controls(P<0.01).The levels of HA and Ⅳ C in patients with severe hepatitis,hepatitis cirrhosis were higher than that of acute hepatitis(P<0.01).The levels of HA and Ⅳ C showed no correlation with the levels of ALT and AST(P>0.05). 〓Conclusion〓 Liver function indices are abnormal in hepatitis B patients.The combined detection of hepatic fibrosis and liver function indices can improve the reliability for the clinical diagnosis of hepatic fibrosis.It is helpful for monitoring and treating hepatitis B.
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