文章摘要
李锦,孟岚,程灏,韩如泉*.全麻状态下颅内动脉瘤夹闭术患者脑脊液中促红细胞生成素的变化[J].山西医科大学学报,2009,40(1):78~80
全麻状态下颅内动脉瘤夹闭术患者脑脊液中促红细胞生成素的变化
Dept of Anesthesiology,Beijing Tiantan Hospital,Capital Medical University, Beijing 100050,China; *Corresponding author,E mail:roughandfuzzy@sohu.com
  修订日期:1900-01-01
DOI:
中文关键词: 促红细胞生成素  颅内动脉瘤  脑脊液  脑保护
英文关键词: erythropoietin  intracranial aneurysm  cerebrospinal fluid  neuroprotection
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作者单位
李锦,孟岚,程灏,韩如泉* 首都医科大学附属北京天坛医院麻醉科北京100050*通讯作者E mail:roughandfuzzy@sohu.com 
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中文摘要:
      目的〓 观察颅内动脉瘤夹闭术患者围术期全身麻醉后不同时间点的促红细胞生成素(EPO)的变化规律。 〓方法〓 随机选择ASAⅠ-Ⅲ级颅内动脉瘤夹闭术患者30例,Hunt Hess分级Ⅰ-Ⅲ级,静吸复合全身麻醉,腰穿取不同时间点(麻醉诱导后、动脉瘤夹闭后即刻,术后2,4和24 h)采集脑脊液,用酶联免疫吸附法检测脑脊液的EPO浓度。 〓结果〓 30例患者2例术后24 h死亡,他们的EPO值均高于同期研究者数倍,余28例不同时间点EPO值由高到低依次为:术后2 h>动脉瘤夹闭后即刻>术后4 h>术后24 h>麻醉诱导后,麻醉诱导后和各不同时间点间比较均有统计学差异。 〓结论〓 颅内动脉瘤夹闭术患者EPO的升高与术中机体受到伤害性刺激的损伤程度相一致,EPO应激性升高可能起脑保护作用,但体内的EPO并不能逆转损伤的进程。
英文摘要:
      Objective〓 To investigate the changes of erythropoietin (EPO)in cerebrospinal fluid in patients undergoing clipping of intracranial aneurysm. 〓Methods〓 Thirty ASA Ⅰ Ⅲ patients undergoing clipping of intracranial aneurysm were anesthetized.After tracheal intubation,lumbar puncture was performed in patients.The levels of EPO in cerebrospinal fluids were determined after by enzyme linked immunosorbent assay(ELISA)intubation,at the time of clipping aneurysm,at hour 2, 4,24 after surgery,respectively. 〓Results〓 Of 30 patients,two patients died after surgery,with higher EPO than that of the others. The EPO levels decreased at hour 2 after surgery,clipping aneurysm,at hour 4 after surgery,at hour 24 after surgery,after tracheal intubation in turns.Compared with that after tracheal intubation,EPO level showed a significant difference at the other time points. 〓Conclusion〓 The EPO level is coincident with the degree of surgery injury, and the increase of EPO may be favorable to neuroprotection.However,endogenous EPO could not reverse the development of the injury.
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