文章摘要
刘爱琳1*,张宏文2.小儿静脉滴注阿奇霉素时胃肠道副反应的防治[J].山西医科大学学报,2009,40(1):89~91
小儿静脉滴注阿奇霉素时胃肠道副反应的防治
1Dept of Pediatrics,First People’s Hospital of Yunnan Province, Kunming 650032,China;2Dept of Pediatrics,First Hospital of Peking University; *〖KG-*4〗Corresponding author,E mail:ailinliu@yeah.net
  
DOI:
中文关键词: 硫酸铝凝胶  蒙脱石散剂  阿奇霉素  副反应
英文关键词: aluminum phosphate  dioctahedral smectite  azithromycin  side effects
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作者单位
刘爱琳1*,张宏文2 1云南省第一人民医院儿科昆明6500322北京大学第一医院儿科*通讯作者E mail:ailinliu@yeah.net 
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中文摘要:
      目的〓 比较磷酸铝凝胶(aluminum phosphate)和蒙脱石散剂(dioctahedral smectite)对小儿阿奇霉素静滴时胃肠道副反应的防治效果。 〓方法〓 315例支原体肺炎患儿,随机分为硫酸铝凝胶组、蒙脱石散剂组和对照组,各105例。观察三组在阿奇霉素静滴时胃肠道副反应(包括腹痛、腹泻、恶心、呕吐)的发生情况。 〓结果〓 硫酸铝凝胶组和蒙脱石散剂组阿奇霉素静滴后胃肠道副反应发生率明显低于对照组(P<0.01),硫酸铝凝胶组的发生率较蒙脱石散剂组更低(P<0.05)。三组的治疗效果无统计学差异(P>0.05)。 〓结论〓 硫酸铝凝胶、蒙脱石散剂可明显减少阿奇霉素的胃肠道副反应,尤以硫酸铝凝胶的效果显著。
英文摘要:
      Objective〓 To compare the preventive effects of aluminum phosphate and dioctahedral smectite on side effects of azithromycin for the gastrointestinal tract in children with Mycoplasma pneumoniae. 〓Methods〓 A total of 315 children with Mycoplasma pneumoniae were randomized into three groups:aluminum phosphate group,dioctahedral smectite group and control group.Side effects of azi thromycin for the gastrointestinal tract among three groups were compared. 〓Results〓 The incidence rate of side effects was significantly lower in aluminum phosphate group and dioctahedral smectite group than in control group(P<0.01),and lower in aluminum phosphate group than in dioctahedral smectite group(P<0.05).The curative effect showed no significant difference among three groups(P>0.05). 〓Conclusion〓 Aluminum phosphate and dioctahedral smectite,especially the former,can decrease side effects of azithromycin for the gastrointestinal tract in children.
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