文章摘要
连婧1,李丽2,孙瑞芳2,王全红2*.乳腺癌组织中Ki67、C erbB 2、VEGF表达的相关性及临床意义[J].山西医科大学学报,2009,40(2):125~127
乳腺癌组织中Ki67、C erbB 2、VEGF表达的相关性及临床意义
Correlation of Ki67,C erbB 2 and VEGF expression in breast cancer and their clinical significance
  
DOI:
中文关键词: 乳腺癌  Ki67  VEGF  C erbB 2
英文关键词: breast cancer  Ki67  VEGF  C erbB 2
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作者单位
连婧1,李丽2,孙瑞芳2,王全红2* 1山西医科大学病理教研室太原0300012山西省肿瘤医院病理科*通讯作者E mail:wangrenk@public.ty.sx.cn 
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中文摘要:
      目的〓 探讨乳腺癌中增殖细胞核抗原(Ki67)、人表皮生长因子-2(C erbB 2)、血管内皮生长因子(VEGF)的表达与临床病理因素的关系及临床意义。 〓方法〓 采用免疫组化法检测42例乳腺癌标本Ki67、C erbB 2、VEGF的表达,并与临床病理因素进行相关性分析。 〓结果〓 在42例乳腺癌中,Ki67的表达与乳腺癌临床分期相关(P<0.05);C erbB 2的表达与乳腺癌临床分期、淋巴结转移状况有关(均P<0.05);VEGF的表达与淋巴结转移状况相关(P<0.05);Ki67和C erbB 2、Ki67和VEGF的共同表达阳性均与乳腺癌临床分期、淋巴结转移状况显著相关(均P<0.05)。 〓结论〓 Ki67、C erbB 2和VEGF的阳性表达可以作为乳腺癌发生、发展的评价指标,三者联合检测更加有助于乳腺癌患者的临床治疗和预后判断。
英文摘要:
      Objective〓 To investigate the expression of Ki67,C erbB 2 and VEGF in breast cancer,and to explore its relationship with clinicopathological factors and its clinical significance. 〓Methods〓 The expression of Ki67,C erbB 2 and VEGF in 42 cases of breast cancer was assessed by immunohistochemistry,and their correlations with clinicopathological factors were statistically analyzed. 〓Results〓 In 42 cases of breast cancer,the expression of Ki67 was related with clinical stage(P<0.05);the expression of C erbB 2 was related with clinical stage and lymph node status(P<0.05);the expression of VEGF was related with lymph node status(P<0.05).The co expression of Ki67 and C erbB 2,Ki67 and VEGF was related to clinical stage and lymph node metastasis(P<0.05). 〓Conclusion〓 Ki67,C erbB 2 and VEGF may be biological markers for estimating the occurrence and progression of breast cancer.Combined detection of Ki67,C erbB 2 and VEGF may contribute to clinical treatment and prognostic judgment of breast cancer.
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