| 刘莹，霍丽娟，张锁娟.缬沙坦治疗肝硬化门静脉高压症患者的临床观察[J].山西医科大学学报,2009,40(2):147~149 |
| 缬沙坦治疗肝硬化门静脉高压症患者的临床观察 |
| Effect of valsartan on portal hypertension in patients with hepatic cirrhosis |
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| DOI： |
| 中文关键词: 缬沙坦 肝硬化 彩色多普勒超声 降钙素基因相关肽 |
| 英文关键词: valsartan hepatic cirrhosis color Doppler calcitonin gene related peptide |
| 基金项目: |
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| 中文摘要: |
| 目的〓
探讨缬沙坦对肝硬化患者血流动力学及降钙素基因相关肽（CGRP）的影响。
〓方法〓
肝硬化患者分为对照组和治疗组，各18例，对照组给予常规治疗，治疗组在此基础上加用缬沙坦80 mg/d口服，疗程1个月。治疗前后应用彩色多普勒超声仪检测门、脾静脉的内径与流速并计算血流量，同时采用放免法检测血浆CGRP的水平。
〓结果〓
治疗组患者门、脾静脉的内径减小，流速增快，门静脉血流量增加，血CGRP水平明显下降，而对照组上述指标的变化均无统计学意义。
〓结论〓
缬沙坦能够通过降低血CGRP水平的途径降低门静脉压力。 |
| 英文摘要: |
| Objective〓
To explore the effect of valsartan on hemodynamics and calcitonin gene related peptide(CGRP)in patients with hepatic cirrhosis.
〓Methods〓
Thirty-six patients with hepatic cirrhosis were divided into control group and treatment group.Eighteen patients in control group received routine treatment for 1 month and eighteen patients in treatment group received valsartan 80 mg/d based on routine treatment for 1 month.Diameter of portal or splenic vein and their velocity were measured before and after treatment by color Doppler.The flow volume was calculated.CGRP was simultaneously assessed by radioimmunoassay.
〓Results〓
In treatment group,the diameter of portal or splenic vein reduced after treatment（P<0.05）,〖JP2〗and the mean velocity of portal or splenic vein and the blood flow of portal vein increased（P<0.05）.The blood concentration of CGRP decreased in treatment group after treatment（P<0.05）.The above mentioned markers showed no statistically significant difference before and after treatment in control group.
〓Conclusion〓
Valsartan can decrease the portal pressure in patients with PHT by reducing blood levels of CGRP. |
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