文章摘要
张锁娟,霍丽娟,刘莹.缬沙坦对肝硬化门静脉高压症患者ET、NO、TNF α浓度的影响及意义[J].山西医科大学学报,2009,40(2):150~152
缬沙坦对肝硬化门静脉高压症患者ET、NO、TNF α浓度的影响及意义
Effects of valsartan on ET,NO and TNF α in hepatic cirrhosis patients with portal hypertension and its significance
  
DOI:
中文关键词: 门静脉高压  肝硬化  缬沙坦  血管活性物质
英文关键词: portal hypertension  hepatic cirrhosis  valsartan  vasoactive substances
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作者单位
张锁娟,霍丽娟,刘莹 山西医科大学第一临床医学院消化科太原030001 
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中文摘要:
      目的〓 探讨缬沙坦对肝硬化门静脉高压症患者(PHT)ET、NO、TNF α浓度的影响。 〓方法〓 36例肝硬化门静脉高压症患者,随机分为两组:对照组和治疗组,每组各18例。对照组给予常规保肝治疗,治疗组在此基础上加用缬沙坦80 mg/d,疗程为1个月。治疗前后采用放射免疫法检测血浆ET、血清TNF α浓度,硝酸还原酶法检测血清NO浓度。 〓结果〓 治疗组在加用缬沙坦后,ET、NO、TNF α均较治疗前明显降低(P<0.05)。对照组治疗后ET、NO、TNF α也有所降低,但差异无统计学意义(P>0.05)。两组治疗前后差值比较,差异有统计学意义(P<0.05)。 〓结论〓 缬沙坦可能通过改变血管活性物质的浓度降低肝硬化门静脉压力。
英文摘要:
      Objective〓 To explore effects of valsartan on endothelin(ET),nitric oxide(NO)and tumor necrosis factor alpha(TNF α)in hepatic cirrhosis patients with portal hypertension. 〓Methods〓 Thirty six hepatic cirrhosis patients with portal hypertension were randomized into two groups:valsartan group(n=18)and control group(n=18).The patients were treated with routine treatment for 1 month in control group, while the patients were treated with valsartan(80 mg/d)based on routine treatment for 1 month in valsartan group.Before and after treatment,plasma ET and serum TNF α were measured by radioimmunoassay,and serum NO concentration was measured by the method of nitric acid reductase. 〓Results〓 In valsartan group,the levels of ET,NO and TNF α were significantly lower after treatment than that before treatment,respectively(P<0.05).In control group,the levels of ET,NO and TNF α after treatment were lower than that before treatment,but there was no statistically significant difference(P>0.05).The difference of ET,NO and TNF α before and after treatment was statistically significant between two groups(P<0.05). 〓Conclusion〓 Valsartan could reduce portal hypertension in patients with hepatic cirrhosis at some extent by changing the level of vasoactive substances.
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