| 陈玺，肖延风，刘雅，任利芬.抗凋亡基因survivin在白血病中的表达及其临床意义[J].山西医科大学学报,2009,40(2):156~158 |
| 抗凋亡基因survivin在白血病中的表达及其临床意义 |
| Expression of survivin in leukemia and its clinical significance |
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| DOI： |
| 中文关键词: 白血病 survivin表达 蛋白印迹法 |
| 英文关键词: leukemia survivin expression Western blotting |
| 基金项目:陕西省自然科学基金资助项目（2002C239） |
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| 中文摘要: |
| 目的〓
研究白血病患者survivin的表达及其在临床上的意义。
〓方法〓
应用蛋白印迹法检测18例白血病患者化疗前和10例正常对照组外周血中单个核细胞survivin蛋白的表达，并与患者的临床特点进行相关性分析。
〓结果〓
18例白血病患者中13例survivin表达阳性，而在正常对照组中检测均为阴性。急非淋组survivin表达显著高于急淋组；WBC＞6.0×109组survivin表达显著高于WBC＜6.0×109组（P<0.05）；但在不同年龄、性别、急淋或急非淋的亚型、急/慢性、首发/复发组之间差异均无统计学意义（P>0.05）。
〓结论〓
survivin基因可选择性地在白血病细胞中表达，提示survivin表达与白血病的发生有一定的关系。 |
| 英文摘要: |
| Objective〓
To explore the expression of survivin in leukemia and its clinical significance.
〓Methods〓
Expression of survivin in peripheral blood mononuclear cells was detected in 18 leukemia patients and 10 normal controls using Western blotting.
〓Results〓
Expression of survivin was positive in 13 of 18 leukemia patients,but negative in all of 10 normal controls.The expression of survivin was significantly higher in patients with acute nonlymphocytic leukemia than that in patients with acute lymphoblastic leukemia,and it was also higher in patients with WBC＞6.0×109 than that in patients with WBC＜6.0×109(P<0.05).The survivin expression had no significant difference in patients with different age,sex,acute/chronic leukemia,primary/relapse(P>0.05).
〓Conclusion〓
The survivin could be selectively expressed in leukemia cells,which indicates that expression of survivin gene may be related to the pathogenesis of leukemia. |
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