| 宋志宇1，〓姚汉武1，〓宋广叶2.卵巢颗粒细胞瘤中Ki67和FOXL2的表达与临床病理参数的关系[J].山西医科大学学报,2009,40(3):240~242 |
| 卵巢颗粒细胞瘤中Ki67和FOXL2的表达与临床病理参数的关系 |
| Correlation of expression of Ki67 and FOXL2 with clinicopathological parameters in ovarian granulosa cell tumor |
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| DOI： |
| 中文关键词: 卵巢颗粒细胞瘤 〓Ki67 〓FOXL2 |
| 英文关键词: ovarian granulosa cell tumors 〓Ki67 〓FOXL2 |
| 基金项目: |
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| 中文摘要: |
| 目的〓
探讨卵巢颗粒细胞瘤中增殖细胞相关核抗原（Ki67）和FOXL2的表达及意义。
〓方法〓
采用免疫组化EnVision二步法检测Ki67和FOXL2在37例卵巢颗粒细胞瘤中的表达，并分析与临床病理参数的关系。
〓结果〓
随临床分期升高卵巢颗粒细胞瘤组织中Ki67和FOXL2表达水平均升高（P＜0.05），核分裂相≥3/HPF组中的表达明显高于核分裂相＜3/HPF组（P＜0.05）；在复发组中Ki67表达高于原发组（P＜0.05）；在成年型卵巢颗粒细胞瘤中弥漫型组的Ki67和FOXL2表达高于滤泡型组（P＜0.05）。
〓结论〓
Ki67和FOXL2可以作为卵巢颗粒细胞瘤的辅助诊断指标，测定它们的表达可为诊断及判断预后提供理论依据。 |
| 英文摘要: |
| Objective〓
To explore the expression of Ki67 and FOXL2 in human ovarian granulosa cell tumors(GCT)and its clinical significance.
〓Methods〓
The expression of proliferation cell nuclear antigen Ki67 and FOXL2 was measured in 37 cases of ovarian granulosa cell tumors by immunohistochemical method.
〓Results〓
The expression of Ki67 and FOXL2 gradually increased in clinical stageⅠ,Ⅱ,Ⅲ.The expression of Ki67 and FOXL2 in human ovarian granulosa cell tumors with karyokinesis≥3/HPF was higher than that with karyokinesis＜3/HPF.The expression of Ki67 in recurrent cases was higher than that in primary cases(P＜0.05).The expression of Ki67 and FOXL2 in diffuse pattern of adult granulosa cell tumors was significantly higher than in follicular pattern.
〓Conclusion〓
Ki67 and FOXL2 can be served as subsidiary tumor markers,and their expression can provide a theoretical basis for diagnosis and prediction of ovarian GCT. |
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