| 李晓玲,〓霍丽娟.谷氨酰胺对肝硬化患者肠屏障保护作用的研究[J].山西医科大学学报,2009,40(3):261~263 |
| 谷氨酰胺对肝硬化患者肠屏障保护作用的研究 |
| Protective effect of glutamine on intestinal barrier in hepatic cirrhosis patients |
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| DOI： |
| 中文关键词: 谷氨酰胺 〓肝硬化 〓肠黏膜屏障 〓肠源性内毒素血症 |
| 英文关键词: glutamine 〓hepatic cirrhosis 〓intestinal barrier 〓intestinal endotoxemia |
| 基金项目: |
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| 中文摘要: |
| 目的〓
探讨谷氨酰胺对肝硬化患者肠屏障功能的保护作用。
〓方法〓
将40例确诊为肝硬化患者随机分为研究组（常规治疗+谷氨酰胺）和对照组（常规治疗），治疗6周后，比较各组治疗前后内毒素、二胺氧化酶、肿瘤坏死因子α、尿乳果糖/甘露醇排泄比水平的变化。
〓结果〓
治疗6周后，研究组内毒素水平较治疗前降低；对照组内毒素水平治疗前后无统计学差异。治疗6周后两组尿乳果糖/甘露醇排泄比、二胺氧化酶、肿瘤坏死因子α均较治疗前降低（P<0.05）。研究组各项数据在治疗前后变化幅度较对照组明显（P<0.05）。
〓结论〓
谷氨酰胺能够显著降低肝硬化患者血清内毒素水平，有效保护肠黏膜屏障功能。 |
| 英文摘要: |
| Objective〓
To investigate the effect of glutamine（GLN）on intestinal barrier of hepatic cirrhosis patients．
〓Methods〓
Forty patients with hepatic cirrhosis were randomly allocated into two groups：experimental group and control group．The patients in experiment group received oral administration of glutamine based on conventional treatment，while the patients in control group received conventio nal treatment．The levels of endotoxin，diamine oxidase，tumor necrosis factor α(TNF α）and urinary lactulose/mannitol(L/M)ratio were determined after treatment for six weeks．The data were compared before and after treatment in 2 groups．
〓Results〓
After six weeks，the content of endotoxin in experimental group was lower than that before treatment(P<0.05)，but there was no significant difference in control group(P>0.05)．The contents of diamine oxidase，TNF α and urinary L/M ratio were lower after treatment than that before treatment(P<0.05).However，the change scope in experimental group was significantly higher than that in control group(P<0.05)．
〓Conclusion〓
Oral administration of glutamine granules can obviously reduce the endotoxin level in hepatic cirrhosis patient，and effectively maintain the function of intestinal barrier． |
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