文章摘要
马宏宾,鲍民生*.MCP 1在急性重症胰腺炎中的表达及意义[J].山西医科大学学报,2009,40(4):316~317
MCP 1在急性重症胰腺炎中的表达及意义
Expression of MCP 1 in severe acute pancreatitis and its significance
  
DOI:
中文关键词: 单核细胞趋化因子-1  〓急性重症胰腺炎  〓多脏器功能不全综合征
英文关键词: monocyte chemotactic protein 1  〓severe acute pancreatitis  〓multiorgan dysfunction syndrome
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作者单位
马宏宾,鲍民生* 山西医科大学第一临床医学院普外科太原030001
*通讯作者 Tel:0351-4639598 
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中文摘要:
      目的〓 研究单核细胞趋化因子-1(MCP 1)在早期急性重症胰腺炎(SAP)模型中的表达。 〓方法〓 以3%牛磺胆酸钠逆行胆胰管注射制作大鼠SAP模型,检测血清淀粉酶,于镜下观察组织的病理学变化;采用免疫组织化学方法对雄性SD大鼠SAP模型组(术后4 h及12 h)及正常对照组小肠(空肠)、肝脏组织标本中MCP 1的表达进行检测。 〓结果〓 MCP 1主要表达于胞质,SAP模型组小肠(空肠)、肝脏组织中的MCP 1表达明显高于正常对照组(P<0.001)。 〓结论〓 MCP 1的高度表达在SAP发生发展中具有重要作用,表明其对多脏器功能不全综合征(MODS)具有重要影响作用。
英文摘要:
      Objective〓 To explore the potential role of monocyte chemotactic protein 1(MCP 1)in early severe acute pancreatitis(SAP). 〓Methods〓 SAP rat models were induced by retrograde injection of 3% sodium taurocholate into the bilipancreatic duct.The activity of serum amylase was measured and the histopathological changes were observed under electron microscope.Immunohistochemistry method was used for detecting MCP 1 expression in SAP rats after operation for 4 h and 12 h and normal controls. 〓Results〓 MCP 1 was mainly expressed in endochylema.The expression of MCP 1 in tissues of intestine(jejunum),liver were significantly higher than that in normal controls. 〓Conclusion〓 MCP 1 might play an important role in the pathogenesis of early SAP,indicating that it has an important influence on the formation of multiorgan dysfunction syndrome(MODS).
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