| 杜毓锋，刘学军，钱力.丙氨酰-谷氨酰胺治疗老年慢性阻塞性肺疾病急性加重期的临床观察[J].山西医科大学学报,2009,40(4):336~338 |
| 丙氨酰-谷氨酰胺治疗老年慢性阻塞性肺疾病急性加重期的临床观察 |
| Effects of alanyl glutamine on acute exacerbation of chronic obstructive pulmonary disease in aged patients |
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| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 〓丙氨酰谷氨酰胺 〓营养治疗 |
| 英文关键词: chronic obstructive pulmonary disease 〓alanyl glutamine 〓nutrition treatment |
| 基金项目: |
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| 中文摘要: |
| 目的〓
探讨丙氨酰谷氨酰胺对慢性阻塞性肺疾病急性加重期患者（AECOPD）的治疗作用。
〓方法〓
选择60例AECOPD 患者，随机分为治疗组和对照组，各30例。对照组给予常规临床治疗，抗生素使用14 d。治疗组在对照组的基础上加用丙氨酰谷氨酰胺治疗，观察两组治疗前、治疗第10天及第14天的动脉血气，治疗前及治疗第14天的肝肾功能、血清白蛋白、总蛋白的变化，并评价治疗效果。
〓结果〓
治疗组动脉血气分析在第10天与对照组比较有统计学差异（P＜0.05），治疗期间各营养指标明显高于对照组（P＜0.05），肝肾功能无统计学差异（P＞0.05），疗效评价治疗组与对照组相比有统计学差异（P＜0.05）。
〓结论〓
联合应用丙氨酰谷氨酰胺对AECOPD患者有明显的治疗作用。 |
| 英文摘要: |
| Objective〓
To evaluate the value of alanyl glutamine in the treatment of aged patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).
〓Methods〓
Sixty aged patients with AECOPD were randomly divided into two groups：control group（n=30）and treatment group(n=30).The patients in control group were given the conventional treatment for 14 d,and patients in treatment group were given alanyl glutamine for 14 d based on conventional treatment.Before and after treatment,the arterial blood gas analysis was observed,liver and kidney functions,seralbumin and total serum protein were detected,and the clinical effects were evaluated.
〓Results〓
At day 10,the arterial blood gas analysis in treatment group was better than that in control group（P＜0.05）.During the whole treatment,all nutrition indices were higher than that in control group（P＜0.05）.The clinical effects in treatment group were better than that in control group（P＜0.05）,but the liver and kidney functions showed no significant difference between two groups（P＞0.05）.
〓Conclusion〓
Conventional treatment combined with alanyl glutamine could effectively treat AECPD in the aged patients. |
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