文章摘要
王玉贤,韩周红,土增荣.米非司酮对早孕妇女血清层粘连蛋白及Ⅳ型胶原纤维的影响[J].山西医科大学学报,2009,40(4):363~365
米非司酮对早孕妇女血清层粘连蛋白及Ⅳ型胶原纤维的影响
Effects of mifepristone on laminin and collagen Ⅳ in early pregnant women
  
DOI:
中文关键词: 米非司酮  〓早孕  〓层粘连蛋白  〓Ⅳ型胶原纤维
英文关键词: mifepristone  〓early pregnancy  〓laminin  〓collagen Ⅳ
基金项目:
作者单位
王玉贤,韩周红,土增荣 山西医科大学第一临床医学院妇产科太原030001 
摘要点击次数: 501
全文下载次数: 0
中文摘要:
      目的〓 探讨服用米非司酮后早孕妇女血清层粘连蛋白(LN)和Ⅳ型胶原纤维(Ⅳ·C)水平变化及其意义。 〓方法〓 采用放射免疫分析法对20例早孕妇女口服米非司酮前后血清中LN和Ⅳ·C进行检测。 〓结果〓 20例早孕妇女口服米非司酮后血清中LN的含量[(78.78±27.00)ng/ml]高于服药前[(70.04±21.79)ng/ml,P<0.05];服药后血清中Ⅳ·C的含量[(35.20±12.58)ng/ml],与服药前[(36.03±12.30)ng/ml]比较,差异无统计学意义(P=0.578)。 〓结论〓 口服米非司酮可使早孕妇女血清中LN的含量升高,而对Ⅳ·C的含量无影响。LN可能参与米非司酮引起的流产机制,并在早期妊娠的持续中起重要的作用。
英文摘要:
      Objective〓 To explore the effect of mifepristone on the serum levels of laminin(LN),collagen Ⅳ and its significance. 〓Methods〓 Twenty early pregnant women were enrolled for the study.The serum levels of LN and collagen Ⅳ were determined before and after treated with mifepristone. 〓Results〓 After treatment,the mean value of LN in serum was(78.78±27.00)ng/ml,significantly higher than that before treatment[(70.04±21.79)ng/ml,P<0.05].The mean value of collagen Ⅳ in serum of early pregnant women was lower after treatment than that before treatment[(35.20±12.58)ng/ml vs (36.03±12.30)ng/ml],but there was no significant difference. 〓Conclusion〓 Mifepristone can elevate the levels of LN in women with early pregnancy,but have no effect on the levels of collagen Ⅳ in women with early pregnancy.LN may be responsible for the early pregnancy,and may take part in the abortion mechanism of mifepristone.
查看全文   查看/发表评论  下载PDF阅读器
关闭