文章摘要
杜俊玲,李亚蕊*.血小板活化因子在川崎病中的变化及临床意义[J].山西医科大学学报,2009,40(4):365~367
血小板活化因子在川崎病中的变化及临床意义
Changes of platelet activating factor in Kawasaki disease and its clinical significance
  
DOI:
中文关键词: 川崎病  〓血小板活化因子  〓冠状动脉损伤
英文关键词: Kawasaki disease  〓platelet activating factor  〓coronary artery lesion
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作者单位
杜俊玲,李亚蕊* 山西医科大学儿科医学系太原030001*通讯作者E mail:zyl3212008@sina.com 
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中文摘要:
      目的〓 探讨川崎病患儿血浆血小板活化因子(PAF)的变化及其临床意义。 〓方法〓 收集川崎病患儿40例(其中冠状动脉损伤组16例,无冠状动脉损伤组24例),按病程分为急性期和恢复期;20例健康儿童为对照组。测定其血浆PAF的含量。 〓结果〓 川崎病组患儿急性期与恢复期PAF含量均高于对照组(P<0.05);急性期PAF含量高于恢复期(P<0.05)。急性期冠状动脉损伤组PAF含量明显高于非冠状动脉损伤组(P<0.05)。川崎病组患儿急性期PAF含量与冠脉扩张呈正相关。 〓结论〓 血浆PAF可能参与了川崎病的病理生理过程,且可能与冠状动脉的损伤有一定的关系。
英文摘要:
      Objective〓 To investigate the plasma levels of platelet activating factor(PAF)in children with Kawasaki disease(KD),and to explore its clinical significance. 〓Methods〓 Forty in patient children with KD including 16 children with coronary artery lesion and 24 children without coronary artery lesion were enrolled.According to disease course,the patients were divided into acute phase group and convalescent phase group.Twenty children with normal physical examination were enrolled as control group.Plasma levels of PAF were measured. 〓Results〓 Compared with control group,plasma levels of PAF increased in KD group(P<0.05).Plasma levels of PAF in acute phase group were higher than that in convalescent phase group(P<0.05).In acute phase,plasma levels of PAF in patients with coronary artery lesion group were higher than that in non coronary artery lesion group(P<0.05).Plasma levels of PAF were positively related with coronary artery lesion in acute phase of KD. 〓Conclusion〓 Plasma PAF might take part in the pathogenesis of KD.Besides,plasma PAF might be associated with coronary arterial lesion in acute phase.
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