文章摘要
徐朝健1,吕智2,刘小丽2,冯毅2.人骨肉瘤中endostatin的表达及其临床意义[J].山西医科大学学报,2007,38(11):999~1001
人骨肉瘤中endostatin的表达及其临床意义
Expression and significance of endostatin in human ost eosarcoma
  
DOI:
中文关键词: 骨肉瘤  内皮抑素  微血管密度  CD34
英文关键词: osteosarcoma  endostatin  microvessel density  CD34
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作者单位
徐朝健1,吕智2,刘小丽2,冯毅2 1山西省人民医院骨科太原 0300012山西医科大学第二临床医学院骨科 
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中文摘要:
      目的 探讨endostatin在人骨肉瘤中的表达及其临床意义。 方法 采用 免疫组化elivision两步法检测30例骨肉瘤和30例骨软骨瘤中endostatin和CD34的表达,并 用SPSS13.0统计软件对endostatin和CD34在骨肉瘤和骨软骨瘤中的阳性表达率以及在骨肉瘤中表达存在的相关关系进行分析。 结果 endostatin和CD34在骨肉瘤中的阳性率分别为93.3%和96.7%,在骨软骨瘤中的阳性率分别为40.0%和16.7 %,两者在骨肉瘤和骨软骨瘤中的阳性表达率均有显著差异(P<0.01)。endostat in与CD34在骨肉瘤中表达存在正相关关系(P<0.05),相关系数rs=0.528,endo statin表达在组织高、低分化间有显著差异(P<0.05),endostatin表达与骨肉瘤转移 有关(P<0.05)。 结论 endostatin可作为术后肿瘤转移的 预测因子及判断预后的指标,检测endostatin为骨肉瘤恶性程度及预后评估提供一定的辅助 参考指标。
英文摘要:
      Objective To explore the expression of endostatin in osteosarcoma and its clinical significance. Methods Expression of endostatin and CD34 was evalua ted by immunohistochemical Elivision method in 30 of specimens of osteosarcoma a nd 30 osteochondroma tissues. The positive expression rates of endostatin, CD34 and their relations were analyzed with soft ware SPSS13.0.Results The positive expression rates of endostatin and CD34 protein in osteosarcoma were 93.3% and 96.7% in osteosarcoma, 40.0% and 16 .7% in osteochondroma respectively, and they had significant difference betwe en osteosarcoma and osteochondroma (P<0.01). In patients with osteosarcoma, expression of endostatin was positively corre lated with expression of CD34 (P<0.05,rs=0.528), and the expression of endostatin was significantly higher in poor differentiation than that in good differentiation (P<0.05). Expression of endostatin was related to osteo sarcoma m etastasis(P<0.05). Conclusion Endostatin could be a marker for predicting postop eration metastasis and prognosis, and expression of endostatin may act as adjuva nt indicators for evaluating grade of malignancy of osteosarcoma.
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