文章摘要
卓丽娟,高美钦.C erbB 2在胃癌中的表达及其与临床病理特征和预后的关系[J].山西医科大学学报,2007,38(11):1021~1023
C erbB 2在胃癌中的表达及其与临床病理特征和预后的关系
Expression of C-erbB-2 protein in gastric carcinoma and its clinicopathol ogical significance
  
DOI:
中文关键词: 胃肿瘤  C-erbB-2  预后
英文关键词: stomach neoplasms  C-erbB-2  prognosis
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作者单位
卓丽娟,高美钦 福建医科大学病理学系福州350004 
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中文摘要:
      目的 观察胃癌中C-erbB-2的表达情况及其与患者年龄、性别、分化程度、淋巴结转移及预后 的关系,探讨C-erbB-2在胃癌中表达的临床病理学意义。 方法 采用 免疫 组化SP法测定75例胃癌组织中C-erbB-2的表达。 结果 淋巴结转移组 的C-erbB-2阳性率高于非转移组(P<0.05);C-erbB-2阴性组患者的预后优于C-erbB-2阳性组(P<0.01);胃癌组织中C-erbB-2表达与肿瘤分化程度及患者的性别、年龄无关。 结论 胃癌组织中C-erbB-2表达与肿瘤淋巴结转移有关,并可作为胃癌预后的 判断指标。
英文摘要:
      Objective To explore the expression of C-erbB-2 protein in gastric carcinoma and its r elationship with clinicopathological features and prognosis. Methods The expression of C-erbB-2 protein in 75 cases of gastric carcinoma was asses sed by immunohistochemistry. Results The positive rate of C-erbB-2 in cases of lymph node metastases was significa ntly higher than those without lymph node metastases(P<0.05). The survival r ate in C-erbB-2 positive cases was significantly lower than in C-erbB-2 ne gative cases(P<0.01). The expression of C-erbB-2 had no correlation with age, sex and differentiation. Conclusion The expression of C-erbB-2 could be used to predict prognosis in patients with gastric carcinoma.
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