文章摘要
王文徽1,刘玉玺1,崔爱琴2,李扬波2.肌阵挛癫痫48例临床治疗与预后分析[J].山西医科大学学报,2007,38(11):1028~1031
肌阵挛癫痫48例临床治疗与预后分析
A clinical analysis of 48 patients with my oclonic epilepsy
  
DOI:
中文关键词: 癫痫,肌阵挛性  预后  病因
英文关键词: epilepsies,myoclonic  prognosis  etiology
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王文徽1,刘玉玺1,崔爱琴2,李扬波2 1山西医科大学癫痫研究所太原0300012山西医科大学第三医院神经内科 liuyuxi2003@163.com 
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中文摘要:
      目的 探讨肌阵挛癫痫的病因、临床特点、治疗及预后。 方法 收集山西医科 大学第 三医院2002-01~2006-09诊断的肌阵挛癫痫住院病例,对其临床资料包括一般临床特 点、临床发作表现、病因、治疗及预后等进行回顾性分析。 结果 在48 例患者中,病因明确者26例,以肌阵挛为唯一的发作类型者有28例,合并全身强直阵挛、失 神等其他类型的发作20例。所有患者的脑电图均记录到了多棘、尖-慢综合波。头颅CT/MRI异常者20例。3例行脑组织病理检查,均为成人型神经元蜡样质脂褐质沉积症,半年后的转 归 均差。多数患者对丙戊酸类药物的反应良好。结论 肌阵挛性癫痫的病 因复杂,临床上以肌阵挛发作为主要表现,若伴有其他类型的发作,肌阵挛不容易引起注意,临床工作者应提高 对此疾病群的重视。肌阵挛癫痫的药物选择非常重要,应首选丙戊酸类药物。
英文摘要:
      Objective To explore the etiology, clinical characteristics, therapy and prognosis of myoclonic epilepsy(ME). Methods The clinical data of ME patients in Third Hospita l of Shanxi Medical University from January, 2002 to September, 2006 were analyzed r etrospectively. Results Of 48 patients, 26 had certain etiol ogical factors, 28 only with myoclonic jerks, 20 combined with generalized tonic clonic seizures, absence seizures, and so on. EEG of all patients had repeatedly paroxysmal sharp or polyspike slow wave. The cranium CT/MRI was abnormal in 20 patients. Three patients had Kuf diseases by pathological examination of brain ti ssue, and all of them had bad prognosis after half a year. The majority of patie nts showed a good response to valproate. Conclusion The etiology of ME is complicated. Myoclonic seizu re is the main manifestation of ME, but it could be accompanied with different t ypes of seizure, so that it is easily ignored. Doctors should pay attention to t he disease. The drug choice of ME is very important, and valproate should be fir st line drug.
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