文章摘要
王亚萍,刘永仙,刘晓斌,田红英.延安地区结核杆菌耐药性监测分析[J].山西医科大学学报,2009,40(1):58~60
延安地区结核杆菌耐药性监测分析
Drug resistance of Mycobacterium tuberculosis in Yan’an
  
DOI:
中文关键词: 结核杆菌  药物耐受性  药物敏感性试验
英文关键词: Mycobacterium tuberculosis  drug resistance  drug sensitivity test
基金项目:延安大学科研基金资助项目(YDK2007-42)
作者单位
王亚萍,刘永仙,刘晓斌,田红英 延安大学医学院微生物免疫学教研室延安716000 
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中文摘要:
      目的〓 了解初治和复治肺结核病人对抗结核化学药物的敏感性。 〓方法〓 收集2006-01~2008-01痰菌阳性标本,用改良罗氏培养基绝对浓度法试验,最终获取培养阳性标本144份,对全部培养阳性标本进行5种抗结核药物异烟肼(INH),利福平(RFP),链霉素(SM),乙胺丁醇(EMB),对氨基酸钠(PAS)的耐药性测定。 〓结果〓 总耐药率为42.36%(61/144);初始耐药率为14.29%(9/63),初始耐多药率为9.52%(6/63);获得性耐药率为64.20%(52/81),获得性耐多药率为38.27%(31/81)。对抗结核药物的耐受,主要是耐受RFP(36.11%,52/144)和INH(33.33%,48/144)。 〓结论〓 获得性耐药率高于初始耐药率,应进一步加强对结核杆菌药物敏感性监测。
英文摘要:
      Objective〓 To investigate initial and acquired drug resistance of Mycobacterium tuberculosis. 〓Methods〓 Tuberculosis positive sputum samples were collected from January 2006 to January 2008.Ameliorative Lowenstein Jensen culture medium was used to detect bacillus positive specimen of pulmonary tuberculosis.A total of 144 samples were affirmed.Drug susceptibility tests against streptomycin(SM),isoniazid(INH),rifampicin(RFP),ethambutol(EMB)and sodium para aminosalicylate(PAS)were detected. 〓Results〓 The total drug resistance rate was 42.〖KG-*5〗36%(61/144).The initial drug resistance rate and initial multi drug resistance rate were 14.29%(9/63)and 9.〖KG-*5〗52%(6/63),respectively.The acquired drug resistance rate and acquired multi drug resistance(MDR)rate were 64.20%(52/81)and 38.27%(31/81),respectively.RFP and INH were primary and secondary resistance drugs,and the drug resistance rates were 36.11%(52/144)and 33.33%(48/144),respectively. 〓Conclusion〓 The acquired drug resistant rate is higher than the initial drug resistance rate.Drug sensitivity of Mycobacteria tuberculousis should be monitored.
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