文章摘要
全红,白小红*,王晓芳.铬天青S-氟罗沙星分光光度法测定粉针剂中氟罗沙星的含量[J].山西医科大学学报,2009,40(1):60~63
铬天青S-氟罗沙星分光光度法测定粉针剂中氟罗沙星的含量
Dept of Pharmaceutical Analysis,School of Pharmacy,Shanxi Medical University, Taiyuan 030001,China; *Corresponding author,Tel:0351-4690071,E mail:bxh246@163.com
  
DOI:
中文关键词: 氟罗沙星  铬天青S  电荷转移化合物  卤键
英文关键词: fleroxacin  chrome azurol S  charge transfer compo und  halogen bonding
基金项目:山西省自然科学基金资助项目(2007011086 )
作者单位
全红,白小红*,王晓芳 山西医科大学药学院药物分析教 研室太原030001*通讯作者Tel:0351-4690071E mail:bxh246@163.com 
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中文摘要:
      目的〓 铬天青S-氟罗沙星分光光度法测定粉针剂中氟罗沙星的含量。 〓方法〓 在一定条件下,氟罗沙星与铬天青S反应生成在518 nm处有最大吸收的n π型1∶1电荷转移 化合物或n σ*型1∶1卤键化合物,利用铬天青S-氟罗沙星分光光度法测定氟罗沙星含量 。 〓结果〓 氟罗沙星的线性范围为0.24-19.20 mg/L(r=0.999 7),检测限为0.018 mg/L,精密度RS D=1.0%,方法回收率为(101±6.5)%。 〓结论〓 天青S-氟罗沙星分光光度法灵敏、简便、快速,可用于粉针剂中氟罗沙星的含量测定。
英文摘要:
      Objective〓 To determine the content of fleroxacin in powder for injection with chrome azuro l S fleroxacin spectrophotometry. 〓Methods〓 Under certain conditions,a molar ratio 1∶1 n π charge transfer or n σ* ha logen bonding compound at 518 nm was formed between fleroxacin and chrome azurol S.The content of fleroxacin was determined by chrome azurol S fleroxacin spect rophotometry. 〓Results〓 Linear range,detection limit,precision(RSD)and recovery for fleroxacin were 0.24 -19.20 mg/L(r=0.999 7),0.018 mg/L,1.0 and (101±6.5)%,respectively. 〓Conclusion〓 Chrome azurol S fleroxacin spectrophotometry is a sensitive,simple and fast met hod,and could be applied to determine the content of fleroxacin.
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