| 孟华，杨桂姣*，张卫国,杨成志.力竭运动对大鼠杏仁核NF κB表达的影响[J].山西医科大学学报,2009,40(4):289~291 |
| 力竭运动对大鼠杏仁核NF κB表达的影响 |
| Effects of exhausted exercise on the expression of NF kappa B in amygdaloid nucleus in rats |
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| DOI： |
| 中文关键词: 力竭运动 〓氧化应激 〓NF κB 〓杏仁核 |
| 英文关键词: exhausted exercise 〓oxidative stress 〓NF κB 〓amygdaloid nucleus |
| 基金项目: |
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| 摘要点击次数: 7257 |
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| 中文摘要: |
| 目的
以大鼠1周力竭游泳为模型，观察力竭运动后大鼠杏仁核NF κB在不同时间点的表达变化。
方法
把40只大鼠随机分为对照组和力竭组。力竭组进行1周力竭游泳训练后,用免疫组织化学技术SABC法检测即刻，6 h,8 h,10 h,12 h，14 h,24 h等不同时间点大鼠脑杏仁核NF κB的表达变化，通过图像分析系统和统计学软件进行图像和数据分析。
结果
与对照组相比，力竭组杏仁核 NF κB表达在6 h开始升高（P<0.05）,8-10 h达高峰（P<0.05）, 12-14 h开始明显回落（P< 0.05）,24 h恢复到正常水平（P>0.05）。
结论
杏仁核NF κB信号系统参与力竭游泳运动引起的氧化应激及神经系统功能活动的改变。 |
| 英文摘要: |
| Objective〓
To explore the activation and variation of NF κB in amygdaloid nucleus in rats after 7 d exhausted swimming exercise.
〓Methods〓
Forty rats were randomly divided into control group and exhausted swimming group.The brains in exhausted swimming group were removed at 0 h,6 h,8 h,10 h,12 h,14 h,24 h after 7 d exhausted exercise. The expression of NF κB was detected by immunohistochemical SABC techniques,and analyzed by imaging analysis system and statistic system.
〓Results〓
Compared with control group,the expression of NF κB in amygdaloid nucleus increased at 6 h in exhausted exercise group(P<0.05),peaked at 8-10 h(P<0.05),started to decrease at 12-14 h(P<0.05),and returned to the normal level at 24 h(P>0.05).
〓Conclusion〓
The results suggest that the NF κB signaling system could be activated in amygdaloid nucleus after exhausted swimming exercise,and the activated NF κB signaling system might mediate exhausted exercise induced oxidative stress and alter the function of nervous system. |
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